William G Kaelin Selected Research

Von Hippel-Lindau Tumor Suppressor Protein

1/2022	Sensitivity of VHL mutant kidney cancers to HIF2 inhibitors does not require an intact p53 pathway.
12/2017	HIF activation causes synthetic lethality between the VHL tumor suppressor and the EZH1 histone methyltransferase.
1/2016	Targeting HIF2 in Clear Cell Renal Cell Carcinoma.
2/2013	The VHL/HIF axis in clear cell renal carcinoma.
10/2010	New cancer targets emerging from studies of the Von Hippel-Lindau tumor suppressor protein.
5/2009	Treatment of kidney cancer: insights provided by the VHL tumor-suppressor protein.
12/2008	Kidney cancer: now available in a new flavor.
3/2007	The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo.
1/2007	The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma.
2/2006	Clusterin is a secreted marker for a hypoxia-inducible factor-independent function of the von Hippel-Lindau tumor suppressor protein.

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William G Kaelin Research Topics

Disease

61	Neoplasms (Cancer) 11/2022 - 04/2002
45	Hypoxia (Hypoxemia) 11/2021 - 03/2002
19	Renal Cell Carcinoma (Grawitz Tumor) 01/2022 - 04/2002
16	Kidney Neoplasms (Kidney Cancer) 11/2022 - 07/2003
13	Carcinogenesis 12/2019 - 03/2002
5	Pheochromocytoma 01/2019 - 08/2005
4	Paraganglioma (Paragangliomas) 11/2021 - 01/2006
4	Breast Neoplasms (Breast Cancer) 10/2018 - 11/2009
4	Retinoblastoma (Glioblastoma, Retinal) 12/2015 - 07/2003
4	Anemia 08/2012 - 03/2008
4	von Hippel-Lindau Disease (von Hippel Lindau Disease) 02/2011 - 09/2002
4	Hemangioblastoma 01/2007 - 09/2002
3	Islet cell tumor syndrome 01/2019 - 08/2005
3	Hereditary Neoplastic Syndromes (Cancer Syndrome, Hereditary) 01/2006 - 11/2003
2	Polycythemia (Erythrocytosis) 11/2021 - 03/2008
2	Multiple Myeloma 01/2021 - 01/2014
2	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2020 - 12/2019
2	Lung Neoplasms (Lung Cancer) 12/2019 - 10/2018
2	Carcinoma (Carcinomatosis) 10/2018 - 04/2010
2	Glioma (Gliomas) 01/2018 - 04/2016
2	Cardiomyopathies (Cardiomyopathy) 03/2014 - 09/2010
2	Renal Insufficiency (Renal Failure) 08/2012 - 07/2010
1	Headache (Headaches) 11/2021
1	Hypertension (High Blood Pressure) 11/2021
1	Genomic Instability 01/2020
1	Esophageal Neoplasms (Esophageal Cancer) 01/2019
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2018
1	Triple Negative Breast Neoplasms 06/2016
1	Neuroblastoma 02/2016
1	Melanoma (Melanoma, Malignant) 12/2015

Drug/Important Bio-Agent (IBA)

31	Transcription Factors (Transcription Factor)IBA 01/2021 - 04/2002
19	Proteins (Proteins, Gene)FDA Link 11/2022 - 04/2002
19	Oxygen (Dioxygen)IBA 10/2020 - 06/2002
14	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2020 - 09/2002
12	Von Hippel-Lindau Tumor Suppressor ProteinIBA 01/2022 - 02/2003
10	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 12/2015 - 10/2002
9	EnzymesIBA 12/2020 - 09/2010
8	UbiquitinIBA 01/2017 - 03/2002
7	Biomarkers (Surrogate Marker)IBA 01/2022 - 04/2003
7	Ligases (Synthetase)IBA 01/2017 - 03/2002
6	Succinate Dehydrogenase (Fumarate Reductase)IBA 12/2020 - 01/2006
6	Histone DemethylasesIBA 12/2019 - 03/2007
5	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2021 - 02/2003
5	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA 12/2020 - 02/2012
5	alpha-hydroxyglutarateIBA 01/2019 - 03/2013
5	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 12/2015 - 07/2003
4	Fumarate Hydratase (Fumarase)IBA 12/2020 - 02/2012
4	Oncogene Proteins (Oncogene Protein)IBA 10/2018 - 03/2004
4	Pharmaceutical PreparationsIBA 01/2017 - 08/2002
3	Small Interfering RNA (siRNA)IBA 11/2022 - 04/2003
3	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 09/2015
3	DioxygenasesIBA 12/2020 - 10/2010
3	Histones (Histone)IBA 01/2019 - 08/2011
3	Cytotoxins (Cytolysins)IBA 10/2009 - 09/2005
2	Thalidomide (Thalomid)FDA Link 01/2021 - 01/2014
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2020 - 01/2007
2	Immune Checkpoint InhibitorsIBA 01/2020 - 02/2018
2	Retinoblastoma ProteinIBA 12/2019 - 08/2011
2	Messenger RNA (mRNA)IBA 01/2019 - 12/2004
2	Mixed Function Oxygenases (Monooxygenases)IBA 01/2019 - 03/2013
2	ChromatinIBA 10/2018 - 08/2011
2	Glutamic Acid (Glutamate)FDA Link 01/2018 - 06/2016
2	Ketoglutaric Acids (Ketoglutaric Acid)IBA 02/2016 - 02/2012
2	FumaratesIBA 02/2016 - 02/2012
2	Succinic Acid (Succinate)IBA 02/2016 - 02/2012
2	Lysine (L-Lysine)FDA Link 11/2012 - 08/2011
2	Erythropoietin FDA Link 08/2012 - 07/2010
2	Retinoblastoma-Binding Protein 2IBA 08/2011 - 03/2007
2	Transforming Growth Factor alpha (TGF-alpha)IBA 01/2007 - 02/2003
2	Retinaldehyde (Retinal)IBA 01/2007 - 09/2002
1	morinIBA 11/2021
1	belzutifanIBA 11/2021
1	Immunomodulating AgentsIBA 01/2021
1	YKL-5-124IBA 01/2020
1	Cre recombinaseIBA 12/2019
1	E2F Transcription FactorsIBA 12/2019
1	AntioxidantsIBA 01/2019
1	Deubiquitinating EnzymesIBA 01/2019
1	Glutathione (Reduced Glutathione)IBA 01/2019
1	Aurora Kinase BIBA 01/2019
1	Programmed Cell Death 1 ReceptorIBA 02/2018
1	Janus KinasesIBA 02/2018
1	GlutaminaseIBA 01/2018
1	Transaminases (Aminotransferases)IBA 01/2018
1	Histone MethyltransferasesIBA 12/2017
1	Biological ProductsIBA 01/2017
1	PT2399IBA 11/2016
1	Cysteine (L-Cysteine)FDA Link 06/2016
1	PT2385IBA 01/2016
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2016
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 01/2016
1	FatsIBA 01/2016
1	Glutamine (L-Glutamine)FDA Link 01/2016
1	AntigensIBA 12/2015
1	Mitochondrial DNA (mtDNA)IBA 12/2015
1	Lactic Acid (Lactate)FDA LinkGeneric 09/2015

Therapy/Procedure

14	Therapeutics 11/2021 - 09/2002
2	Drug Therapy (Chemotherapy) 01/2019 - 04/2016
1	Precision Medicine 04/2016
1	Oral Administration 09/2015